Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Leo, M.A.; Kim., C.I.; Lieber, C.S.
    NAD+-dependent retinol dehydrogenase in liver microsomes (1987), Arch. Biochem. Biophys., 259, 241-249.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.105 Chloral hydrate
-
 Rattus norvegicus
1.1.1.105 additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Peromyscus maniculatus
1.1.1.105 additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Rattus norvegicus
1.1.1.105 SKF525A moderately Peromyscus maniculatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.105 additional information Rattus norvegicus chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition ?
-
 ?
1.1.1.105 additional information Peromyscus maniculatus chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.105 Peromyscus maniculatus
-
-
-
1.1.1.105 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.105 liver
-
 Rattus norvegicus
-
1.1.1.105 liver
-
 Peromyscus maniculatus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.105 additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Rattus norvegicus ?
-
 ?
1.1.1.105 additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Peromyscus maniculatus ?
-
 ?
1.1.1.105 retinal + NADH
-
 Rattus norvegicus retinol + NAD+
-
 r
1.1.1.105 retinal + NADH
-
 Peromyscus maniculatus retinol + NAD+
-
 r
1.1.1.105 retinal + NADPH + H+
-
 Rattus norvegicus retinol + NADP+
-
 ?
1.1.1.105 retinol + NADP+
-
 Peromyscus maniculatus retinal + NADPH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.105 NAD+ cofactor Rattus norvegicus
1.1.1.105 NAD+ cofactor Peromyscus maniculatus
1.1.1.105 NADH cofactor Rattus norvegicus
1.1.1.105 NADH cofactor Peromyscus maniculatus
1.1.1.105 NADP+ cofactor Peromyscus maniculatus
1.1.1.105 NADPH cofactor Rattus norvegicus
1.1.1.105 NADPH cofactor Peromyscus maniculatus